Since her appearance is quite androgynous, and has a preference for Armani suits, she is generally mistaken for a pretty young man.
Chris Sly was left as a baby at a monastery in the Himalayas. Unable to leave the monastery and fearing for her safety, the monks raised her in the monastery, disguised as a boy, where she underwent martial arts training. Unfortunately, the Triad murdered the monks and abducted Chris. They smuggled her to the US along with a bunch of women being trafficked. This is when Chris first discovered her powers. When she arrived in Seattle she was inadvertently rescued by Ransom.
Handsome naturally exhales vapours that, when inhaled, render women unable to resist her. This effect seems to be neutralised by sugar in her mouth so she generally sucks on a lollipop when she wants to avoid deploying her power.